ea0019p330 | Steroids | SFEBES2009
Tiganescu A
, Dekker P
, Mayes A E
, Stewart P
, Walker E A
Topical glucocorticoid therapy causes adverse effects in human skin including a reduction in dermal fibroblast proliferation and extracellular matrix protein secretion (e.g. collagen 1) and epidermal thinning effects paralleled in photoexposed and elderly skin. These cause reduced wound healing rates and a loss of elasticity with increased fragility and transepidermal water loss signs also typical of Cushings syndrome characterised by raised circulating cor...